ABOUT DR. IVAN NG

As Head of Department of Neurosurgery at both Tan Tock Seng Hospital and Singapore General Hospital (National Neuroscience Institute) from 2006-2012, Dr Ivan Ng was responsible for the 2 largest neurosurgical units in the country. He was also the co-director of the Brain and Behavior programme at the Duke-NUS Graduate Medical School from 2007-20013 where he has been an associate professor since 2007. He was the first director of the Khoo Teck Puat NNI Integrated Neuroscience centre at SGH.

A/Prof Ng obtained his medical degree at the National University of Singapore in 1990
and trained at the world renowned Academic Neurosurgical Unit, Addenbrookes Hospital in Cambridge University where he was chief resident from 1999-2000. He obtained the inter-collegiate FRCS (Surgical Neurology) in 2000 and was awarded the prestigious Norman Dott Medal for being the most outstanding candidate during the FRCS examinations.

His previous appointments include Chairman, Chapter of Neurosurgeons, College of Surgeons Singapore and Vice President of the Asian Congress of Neurosurgeons. International committees which A/Prof Ng sits on include the World Federation of Neurological Surgeons International Education Faculty, the ex-co-committee of the International Cerebrovascular Society and the Asia-Oceanic Skull Base Society. He is currently an associate Editor of CNS Oncology and is in the editorial board for the Asian Journal of Neurological Surgeons.

An active educator, he was involved in educating and training neurosurgeons, many of which have been appointed to faculty positions in many countries. He has also conducted many neurosurgical courses and is the course chairman for the yearly Aesculap Academy in Minimally Invasive Neurosurgery, and the AO Foundation course (Asia-Pacific) in neurotrauma.


BIBLIOGRAPHY

Major Accomplishments In Research
I have set up the following laboratories in the Department of Neurosurgery, NNI( over the last 10 years)

1. Neurosurgery Immunohistochemistry Laboratory- which also has rt-PCR, Western blot and cell culture capabilities.

2. High Performance Liquid Chromatography Laboratory

3. Animal Laboratory with the fluid percussion model, subdural model and middle cerebral artery occlusion model with full intensive care monitoring facilities for rodents.

4. Information Technology laboratory which enables high-resolution data collection (5 Hz frequency) of neurological and physiological data from the neuro-intensive care which houses 18 patients.


Neurosurgical/ Professional Committees
1. Exco Member- Society of Intensive Care Medicine Singapore

2. Vice President- Asian Congress of Neurological Surgeons

3. Founding Member- Asia Pacific Coalition against Stroke

4. Editorial Board, Asian Journal of Neurosurgery

5. Review Committee, ICP

6. Course Chairman, Aesculap- NNI Cadaveric Dissection Course( annually)

7. Course Chairman, Instructional Course in Neurosurgery featuring Virtual Reality( annually)

8. Bid Chairman for the 2013 WFNS

9. Bid Chairman for the 2009 ACNS

10. Chairman, Chapter of Neurosurgeons, College of Surgeons, Singapore

11. Member, International Neurotrauma Society

12. Member, ASEAN Society of Neurological Surgeons

13. Member, Clinical Neuroscience Society, Singapore


Administrative Committees
1. Local Organising Committee for ICP 2000 Cambridge

2. Scientific Chairman, 10th ASEAN Congress of Neurological Surgery, Singapore 2002.

3. Organising Committee Asian- Australasian Meeting of Neurological Surgery, Singapore 2003.

4. EXCO Member, Trauma Management Committee (TNT)

5. Bid chairman for WFNS 2013

6. Bid chairman for ACNS 2009

7. Congress chairman for ICP 2013

8. Course chairman for annual Neurosurgical Education Course featuring virtual reality

9. Course chairman for the NNI-Aesculap academy annual cadaveric dissection course


Scientific Papers & Book Chapters Published
1. Closed head injuries in children following the use of a sarong cradle. I Ng, E Seow, L Lee, L Ho; Singapore Medical Journal 1997; 38: 467-468.

2. Outcome of the severely head injured managed on a traumatic brain injury protocol. I Ng, TWK Lew, TT Yeo, Seow WT, KK Tan, PL Ong. Ann Acad Med1998; 27: 332-339.

3. The correlation of outcome to the level of cerebral perfusion pressure achieved. I Ng, TWK Lew, Seow WT, Yeo TT, KK Tan, PL Ong. Proceedings of the 11th International Congress of Neurological Surgery. Moduzzi Editore 11:1293- 1299. 1997.

4. Apoptosis is induced following closed head injury in humans. I Ng, Yeo TT, R Soong, WY Tang, PL Ong, T Lew, HS Goh, and DR Smith. Ann Acad Med 1999; 28: 263-5.

5. Apoptosis occurs following cerebral contusions in humans. I Ng, TT Yeo, WY Tang, R Soong, PY Ng, DR Smith. Neurosurgery 2000; 46: 949-956.

6. Correlation of Favourable Patient outcome in a standardized head injury protocol to the level of cerebral perfusion pressure achieved. I Ng, TWK Lew, TT Yeo, WT Seow, KK Tan, PL Ong. Critical Care Medicine, Jan 1997 Vol 25, No.1 (Suppl) Pg A74.

7. Decision Analytic Approach to Severe Head Injury Management. David Hamanec, Tze-Yun Leong, Suman Sundaresh, Kim Leng Poh, Tseng Tsai Yeo, Ivan Ng, Thomas Lew. Proc AMIA Symp 1999: 271-5.

8. Spinal Cord Injury. I Ng, R.J.C Laing; book chapter in Notes in Neuroanaesthesia and Critical Care edited by A. Gupta and A Sommers published by Greenwich Medical Media Sept 2000.

9. Invited Book Review: Neurosurgery- Scientific basis for clinical practice. Alan Crockard, J Hoffman in British Journal of Neurosurgery 2001; 15 (1): 78.

10. Prospective Study of Clinical and Radiological outcome after Anterior Cervical Discectomy. RJC Laing, I Ng, PJ Hutchinson, HM Br J Neurosurg. 2001 Aug; 15 (4): 319-23.

11. Endoscopic Assisted Microneurosurgery for ruptured aneurysms. ECM Wang, I Ng, PY Ng, PL Ong. J Clin Neuroscience 2003, 10; 2: 174-176.

12. Severe Traumatic Brain Injury Programme at the NNI. I Ng. Neus-Link Vol 1/Dec2000-Feb 2001, Pg 6.

13. The use of Palmar Laser Doppler Flowmetry as an intra-operative adjunct in video-assisted endoscopic sympathectomy. I Ng, TT Yeo. Neurosurgery 52: 127-131.

14. Outcome from Moderate and Severe Traumatic Brain Injury in the Geriatric Population. BK Gan, J Lim, I Ng. Annals Acad Med June 2004; 33: 63-7.

15. Parp is expressed following cerebral contusions in humans. E Yap, I Ng, J Lim, Ang BT. J Neurotrauma 2002; 549.

16. Poly-ADP expression in Traumatic Brain Injury. Ang BT, Tan WL, E Yap, I Ng. J Neurosurg July 2003; 99: 125-130.

17. Spermine reduces infarction and neurological deficit following a rat model of MCA occlusion: a MRI study. Shirhan Md, M Moochala, PY Ng, J Lu, KC Ng, AL Teo, E Yap, I Ng, P Hwang, T Lim, YY Sitoh, H Rumpel, R Jose, E Ling. Neuroscience 124(2004) 299-304.

18. Blood Brain Barrier Disruption following traumatic brain injury: the role of tight junction proteins. I Ng, E Yap, Tan WL, NY Kong. Annals Acad Med 2003; S63-S66.

19. Outcome of moderate and severe traumatic brain injury amongst the elderly in Singapore. Annals Acad Med 2004; 33: 63-67.

20. Imaging Collateral Circulation: MRA and Perfusion MR- Imaging at 3T. Archives of Neurology. Vol 62; Mar 2005, Pg 492. CCT Lim, C Lim, I.Ng.

21. Effects of Head posture on cerebral hemodynamics: its influences on intracranial pressure, cerebral perfusion pressure and cerebral oxygenation. Neurosurgery 2004; 54: 593-598.

22. Patient who talk and deteriorate – A new look at an old problem. JE Tan, I Ng, J Lim, HB Wong, TT Yeo. Ann Acad of Med 2004; 33 (4): 489-493.

23. Surgical management of ruptured and unruptured symptomatic posterior inferior cerebellar artery aneurysms. DNS Liew, PY Ng, I. Ng. Br J Neurosurgery 18:16:608-612, 2002.

24. Apoptosis in acute brain injury- A primer for intensive care physicians. J Wong, Ng WH, ZW Feng, I.Ng. Neurocrit Care. 2005:3(2):177-82. Review.

25. Linear correlation between stable intracranial pressure decrease and regional cerebral oxygenation improvement following mannitol administration in severe acute head injury patients. JGasco, J Sendra, J Lim, I Ng. Acta Neurochirugica Suppl 2005; 95:73-7.

26. Changes in cerebral hemodynamics and cerebral oxygenation during surgical evacuation for hypertensive putaminal hemorrhage. I Ng, E Yap, J Lim. Acta Neurochirugica Supp 2005: 95:97-101.

27. Brain tissue oxygenation - A case for routine monitoring in the neurocritical care? I Ng, J Wong, and Kah Keow Lee. Acta Neurochirugica Supp : 2005; 95:447-51.

28. Cerebrospinal fluid orexin in subarachnoid hemorrhage. Beng Ti Ang, Wan Loo Tan, Joyce Lim, Ivan Ng. J Clin Neurosci. 2005 Sep;12(7):758-62.

29. HIF-1 expression in cerebral arteriovenous malformations. I Ng, E Yap, Ng PY, WL Tan. J Clin Neurosci. 2005 Sep;12(7):794-9.

30. Cerebral revascular- Where are we now? (Editorial Review). Kirkpatrick PJ, I Ng. Journal Neurol, Neurosurg, Psych 2005;76:463-465.

31. Demographic profiles of adult severe traumatic brain injury patients: Implications for healthcare. KK Lee, WT Seow, I.Ng. Singapore Med J. 2006 Jan;47(1):31-6.

32. The implications of Multi-modal Neuro- Monitoring for Nursing. Lee KK, I.Ng. Sing Nursing Journal. 32;4:5-11, 2005.

33. Volume Visualization for Surgical Planning System. Chan CF, I Kassim, C Lo, Kwoh CK, I.Ng. Journal of Mechanics in Med & Biol. Vol 7, No 1(2007) 55-63.

34. MR Regional perfusion Imaging: visualizing functional collateral circulation. T Lim, E Petersen, I.Ng, P Hwang, F Hui, X Golay. AJNR Am J Neuroradiol. 2007 Mar;28(3):447-8.

35. DNA vaccination against neurite growth factors improves neuroplasticity in a rat middle cerebral artery occlusion model. Zhu ZB, Wang TH, WL Tan, E Yap, YL Lee, I.Ng. Submitted to Stroke.

36. Pressure Reactivity and Decompressive Craniectomy. ECM Wang, BT Ang, J Lim, J Wong, I.Ng. BJNS 2005;20( 1)24-30.

37. Gender differences in outcome following severe TBI in a predominan†ly asian population. I.Ng, J Lim, Lim HB, Lee KK. BJNS;2006;20(2):1-6.

38. Experimental analysis on severe head injury outcome prediction- a preliminary study. Hongli Yun, Guo Liang Li, Tze-Yun Leong, Vellasisamy Kuralmani, Boon Chuan Pang, Beng Ti Ang, Kah Keow Lee, Ivan Ng. Submitted to PMIA.

39. Diffusion tensor imaging in a symptomatic patient with an intra-axial arachnoid cyst. J Thorat, YY Sitoh, HC Chin, I.Ng. BJNS April 2006( 20) 2:1-3.

40. Tension pneumoventricle. Radhziah S, Lee C K, Ng I (Full article available). J Clin Neurosci. 2006, Oct 13 (8): 881-3.

41. A randomized trial of synthetic patch versus direct primary closure in carotid endartectomy. Al-Rawi P, Turner C L, Waran V, Ng I, Kirkpatrick P J (Full article available). Neurosurgery 2006 Oct , 59(4): 822-8.

42. Neurosurgical management of intracranial aneurysms following unsuccessful or incomplete endovascular therapy. T Minh, PYK Hwang, KC Nguyen, I. Ng (Full article available). Br J Neurosurgery 2006, Oct 20 (5): 306-311.

43. A hybrid outcome prediction model for severe traumatic brain injury. Pang BC, Kuralmani V, Leong TY, Joshi R, Yin H, Lee KK, Ang BT, Li J, Ng I. (Full article available). J Neurotrauma 2007, Jan 24(1): 136-146.

44. Temporal changes in cerebral vascular reactivity with tissue oxygenation in severe head injury. Ang BT, Wong J, Lee KK, Wang E, Ng I. (Full article available). J Neurol Neurosurg Psychiatry 2007, Mar, 78(3): 298-302.

45. Multi-media Messaging Service (MMS) teleradiology in the provision of emergency neurosurgery services. Ng WH, Wang E, Ng I. (Full article available). Surg Neurol 2007, Apr, 67 : 338-341.

46. Awake craniotomy under local anaesthesia and monitored conscious for resection of brain tumours in eloquent cortex – outcomes in 20 patients. Low D, Ng I, Ng W H. Ann Acad Med Singapore 2007, May, 36(5) : 326–331.

47. Acute Sinus Thrombosis following ingestion of a herbal tonic: case report. Thorat D, I.Ng. J Stroke Cerebrovasc Dis. 2007 Sep-Oct;16(5):232-5.

49. Barbiturate therapy for patients with refractory intracranial hypertension following severe traumatic brain injury. Its effects on tissue oxygenation, brain temperature and autoregulation. Thorat JD, Wang EC, Lee KK, Seow WT, Ng I. J Clin Neurosc 2008 Feb;15(2) 143-8.

50. Virtual Reality Simulation for Skull Base Surgery. Peter Hwang, RA Kokro, CK Lee, I. Ng Asian Journal of Neurosurgery 2007;1:1-8

51. A Collaboratiive Virtual Reality Environment for Neurosurgical Planning & Training. RA Kokro, Stadie A, E Schwandt, Reisch R, Charalampaki, I.Ng, Yeo TT, Hwang P, Sierra L Neurosurgery[ ONS Suppl 2]: ONS379-ONS391, 2007.

52. Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly(ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats;is there additional benefit? Yap E, Tan WL, Ng I, Ng YK. Brain Res. 2007 Dec 23; 2:

53. Effects of glycaemic control on cerebral neurochemistry in primary intracerebral haemorrhage. Ho CL, Ang CB, Lee KK, Ng IH. J Clin Neurosci. 2008 Apr 15(4):428-33.

54. Optimization of ventricular catheter placement via posterior approaches: a virtual reality simulation study. Lee CK, Tay LL, Ng WH, Ng I, Ang BT. Surg Neurol. 2008 Sept;70(3):274-7.

55. Craniospinal Dissemination in Teratocarcinomasarcoma. Case Report. CC Tchoyoson Lim, Anuradha Thiagarajan, Chee Seng Sim, Mark Khoo, Thomas Shakespeare, Ivan Ng. J Neurosurg 109:321-324, Aug 2008.

56. Outcome of Severe Head injured patients admitted to intensive care during weekday shifts compared to nights and weekends. Lee KK, I.Ng, BT Ang. Ann Acad Med Singapore 2008, May 37(5)390-6.

57. Cerebral Oxygenation, vascular reactivity and neurochemistry following decompressive craniectomy for severe traumatic brain injury. Ho CL. Wang CM, Lee KK, I.Ng, BT Ang.J Neurosurg 108(5):943-9 May 2008.

58. Prediction of outcome utilizing both physiological and biochemical parameters in severe head injury. Low D, Kuralmani V, Ng SK, Lee KK, Ng I, Ang BT. J Neurotrauma. 2009 Aug;26(8):1177-82.

59. Stereotaxy for surgical navigation in orbital surgery. Lee KY, Ang BT, Ng I, Looi A. Ophthal Plast Reconstr Surg. 2009 Jul-Aug;25(4):300-2.

60. Telemedicine in emergency neurological service provision in Singapore: using technology to overcome limitations. Singh R, Ng WH, Lee KE, Wang E, Ng I, Lee WL. Telemed J E Health. 2009 Jul-Aug;15(6):560-5.

61. The relationship between parasagittal and falcine meningiomas and the superficial cortical veins: a virtual reality study. Khu KJ, Ng I, Ng WH. Acta Neurochir (Wien). 2009 May 8. [Epub ahead of print]

62. Image-guided robotic neurosurgery--an in vitro and in vivo point accuracy evaluation experimental study. Chan F, Kassim I, Lo C, Ho CL, Low D, Ang BT, Ng I. Surg Neurol. 2009 Jun;71(6):640-7, discussion 647-8. Epub 2009 Mar 28.

63. Surgical planning for microsurgical excision of cerebral arterio-venous malformations using virtual reality technology. Ng I, Hwang PY, Kumar D, Lee CK, Kockro RA, Sitoh YY. Acta Neurochir (Wien). 2009 May;151(5):453-63; discussion 463.

64. Aquaporin-4 expression is increased in edematous meningiomas. Ng WH, Hy JW, Tan WL, Liew D, Lim T, Ang BT, Ng I. J Clin Neurosci. 2009 Mar;16(3):441-3. Epub 2009 Jan 18.

65. Clinical functional magnetic resonance imaging for pre-surgical planning- the Singapore General Hospital experience with the first 30 patients. Rumpel H, Chan LL, Tan JS, Ng IH, Lim WE. Annals Acad Medicine Singaproe 2009 Sep,38(9):782-6.

66. Intra-operative computed angiography in cerebral aneurysm surgery: a pilot feasibility study. Neurosurgery. Dinesh SK, Thomas J, Ng I. 2010 Feb;66(2):349-52.

67. Augmented reality neurosurgical planning and navigation for surgical excision of parasagittal, falcine and convexity meningiomas. Low D, Lee CK, Dip LL, Ng WH, BT Ang, Ng I. Br J Neurosurg. 2010 Feb;24(1), 69-74.

68. Dex-ray augmented reality neurosurgical navigation with a handheld video probe. Kockro RA, TT Yeo, Ng I, P Hwang, Zhu C, Agusanto K, Hong LX, Serra L. Neurosurgery 2009 Oct 65( 4):795-807.